Profile of Dr. Md. Rashedul Islam

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Dr. Md. Rashedul Islam

Professor

Department of Genetics & Animal Breeding (GAB)

Faculty of Veterinary and Animal Science

Hajee Mohammad Danesh Science & Technology University, Dinajpur.

E-mail: mrislam.biotech@hstu.ac.bd

Mobile: +8801711020045


CAREER OBJECTIVE

    Aspire to become an inspiring academician and researcher.

RESEARCH INTEREST

    Reproductive Physiology, Reproductive Toxicology

EDUCATION

  1. Post-doctoral Fellow, 2019

    University of Kansas Medical Center (KUMC), USA

  2. Doctor of Philosophy (PhD) in Agricultural Science, 2016

    Kyushu University, Japan

  3. Master of Science (MSc) in Biotechnology, 2013

    University of the West of Scotland, United Kingdom

  4. Master of Science (MS) in Animal Breeding and Genetics, 2005

    Bangladesh Agricultural University, Mymensingh, Bangladesh

  5. Bachelor of Science (B. Sc.) in Animal Husbandry, 2004

    Bangladesh Agricultural University, Mymensingh, Bangladesh

  6. Higher Secondary Certificate (HSC), 1998

    Bogra Cantonment Public School and College, Bogra, Bangladesh

  7. Secondary School Certificate (SSC), 1996

    Laxmipur High School, Gaibandha, Bangladesh


PROFESSIONAL EXPERIENCES

  1. Professor
    Hajee Mohammad Danesh Science and Technology University (HSTU), Dinajpur, Bangladesh

    May 11, 2021 to Present

  2. Associate Professor
    Hajee Mohammad Danesh Science and Technology University (HSTU), Dinajpur, Bangladesh

    May 11, 2017 to May 10, 2021

  3. Assistant Professor
    Hajee Mohammad Danesh Science and Technology University (HSTU), Dinajpur, Bangladesh

    May 11, 2012 to May 10, 2017

  4. Lecturer
    Hajee Mohammad Danesh Science and Technology University (HSTU), Dinajpur, Bangladesh

    May 11, 2010 to May 10, 2012

  5. Part-Time Teacher
    Hajee Mohammad Danesh Science and Technology University (HSTU), Dinajpur, Bangladesh

    October 28, 2009 to May 10, 2010

  6. Manager (Production)
    National Hatchery and Feed Mill ltd., Gazipur Sadar, Gazipur, Bangladesh

    November 01, 2008 to September 30, 2009

  7. Scientist (Animal Division)
    National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka, Bangladesh

    June 06, 2006 to September 20, 2007

  8. Executive (Animal Breeding)
    Bengal Meat Processing Industries Limited, Korial, Kashinathpur, Santhia, Pabna, Bangladesh

    April 06, 2006 to June 04, 2006


PUBLICATIONS

Journal Papers

  1. Abedin MT, Sujon MN, Fardush R, Islam MN, Islam MR, Sayed MA. Honeyweed (Leonurus sibiricus) supplemented diet on growth performance, blood metabolites, histology, and intestinal microflora of broiler chicks. Vet Res Notes. 2024;4(5):56–64. doi:10.5455/vrn.2024.d43.

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  2. Basher MK, Sarkar S, Haque MS, Sarker S, Islam MR (2024). Protective effect of selenium against arsenic-induced hematological, biochemical alteration, and organ development anomalies in adult female mice. Adv. Anim. Vet. Sci., 12(6):1107-1116.

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  3. Md. Khayrul Basher, Sumon Sarkar, Md. Hosne Mobarak, Md. Rashedul Islam. 2023. Inorganic arsenic exposure during pregnancy affects post-natal growth, blood parameters, and organ development of mice offspring. J Adv Biotechnol Exp Ther. 6(2): 445-457.

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  4. Kazi Ahsan Ahmed, Abu Saim Mohammad Saikat, Akhi Moni, Sadia Akhter Mallik Kakon, Md. Rashedul Islam, Md Jamal Uddin. 2021. Lactoferrin: potential functions, pharmacological insights, and therapeutic promises. J Adv Biotechnol Exp Ther 4(2): 223-237.

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  5. Bhaswati Bhattacharya, Pratik Home, Avishek Ganguly, Soma Ray, Ananya Ghosh, Md. Rashedul Islam, Valerie French, Courtney Marsh, Sumedha Gunewardena, Hiroaki Okae, Takahiro Arima, and Soumen Paul. 2020. Atypical protein kinase C iota ensures mammalian development by establishing the maternal fetal exchange interface. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 117(25):14280-14291.

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  6. Al-Nur Md. Iftekhar Rahman, Seiya Yamashita, Md. Rashedul Islam, Taisuke Fujihara, Hayato Yamaguchi, Manabu Kawahara, Masashi Takahashi, Hideyuki Takahashi, Takafumi Gotoh, Nobuhiko Yamauchi. 2020. Type-I interferon regulates matrix metalloproteinases clearance of the bovine endometrial spheroid. Animal Science Journal 91(1):e13350.

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  7. Sayed A.A. Musavi, Seiya Yamashita, Taisuke Fujihara, Hironori Masaka, Md. Rashedul Islam, Sangwan Kim, Takafumi Gotoh, Manabu Kawahara, Kosuke Tashiro, Nobuhiko Yamauchi. 2018. Analysis of differentially expressed genes and the promoters in bovine endometrium throughout estrus cycle and early pregnancy. Animal Science Journal 89(11):1609-1621.

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  8. Md. Rashedul Islam, Kyohei Nishimura, Ryo Watanabe, Kenji Matsumoto, Shinji Oozono, Kaiyu Kubota, Tomoki Soh, Criss Wood, Kei-ichirou Kizaki, Kazuyoshi Hashizume, Mohamed El-Sharawy and Nobuhiko Yamauchi. Endometrial spheroid generation from rat endometrial stromal cells using salmon atelocollagen for the analysis of endometrial functions. (Ready to submit)

  9. Md. Rashedul Islam, Yuko Ikeguchi, Kazuki Yamagami, Mohamed El-Sharawy, Nobuhiko Yamauchi. 2017. Development of an in vitro model to study uterine functions and early implantation using rat uterine explants. Cell and Tissue Research 370(3):501-512.

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  10. Md. Rashedul Islam, Kazuki Yamagami, Yuka Yoshii, Nobuhiko Yamauchi. 2016. Growth Factor Induced Proliferation, Migration and Lumen Formation of Rat Endometrial Epithelial Cells In Vitro. Journal of Reproduction and Development 62(3):271-278.

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  11. Yamagami Kazuki, Md. Rashedul Islam, Yoshii Yuka, Mori Kazuki, Tashiro Kosuke, Yamauchi Nobuhiko. 2016. Preimplantation embryo-secreted factors modulate maternal gene expression in rat uterus. Cell and Tissue Research 364:453-463.

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  12. Akiyoshi Egashira, Nobuhiko Yamauchi, Md. Rashedul Islam, Kazuki Yamagami, Asami Tanaka, Hikaru Suyama, EL-Sharawy Mohamed EL-Sayed, and Takashi Kuramoto. 2016. Kid depletion in mouse oocytes associated with multinucleated blastomere formation and inferior embryo development. Animal Science Journal 87(8):1048-1054.

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  13. Mohamed El-Sharawy, Entsar Eid, Samy Darwish, Ibrahim ABD El-razek, Md. Rashedul Islam, Kaiyu Kubota, Nobuhiko Yamauchi, Ibrahim El-Shamaa. 2017. Effect of Organic and Inorganic Selenium Supplementation on Semen Quality and Blood Enzymes in Buffalo Bulls. Animal Science Journal 88(7):999-1005.

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  14. Keisuke Yamauchi, Nobuhiko Yamauchi, Kazuki Yamagami, Nobuhisa Nakamura, Seiya Yamashita, Md. Rashedul Islam, Shoji Tabata, Kanji Yahiro, Tomoko Tamura, Kazuyoshi Kashizume and Masa-aki Hattori. 2015. Development of an in vitro model for the analysis of bovine endometrium using simple techniques. Animal Science Journal 86(5):523-531.

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  15. Akiyoshi Egashira, Nobuhiko Yamauchi, Keiko Tanaka, Chihiro Mine, Hitomi Ootsubo, Masao Murakami, Md. Rashedul Islam, Misako Ootsuka, Naomi Yoshioka, and Takashi Kuramoto. 2015. Developmental capacity and implantation potential of the embryos with multinucleated blastomeres. Journal of Reproduction and Development 61(6):595-600.

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  16. Fakruzzaman M., Akter Q.S., Husain S.S., Khandoker M.A.M.Y., Apu A.S. and Md. Rashedul Islam. 2012. Estrus characteristics of black bengal does under intensive condition. Iranian Journal of Applied Animal Science 2(1):89-95.

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  17. Mobarak Akter Md. Yahia KHANDOKER, Syed Sakhawat HUSAIN, Md Shaheb ALI, Md. Raihan ALI, Md. Golam Mostafizur RAHMAN, Md. Rashedul Islam, Auvijit Saha APU, A.H.M. Safiur RAHMAN, Anupom MONDAL, Md. Anisuzzaman MONDAL, K.M.A. TAREQ, Qazi Sharmin AKTER and Hirotada TSUJII. 2008. Biotechnological Approach for the Conservation of Animal Biodiversity in Bangladesh. Journal of the Faculty of Agriculture SHINSHU UNIVERSITY 44(1-2):39-46.

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  18. Afroz, S., Md. Rashedul Islam, M.A.M.Y. Khandoker, Q.S. Akter. 2008. Cryopreservation of Black Bengal buck semen: Effects of diluents and freezing on sperm motility and morphology. Animal Science Journal 79 (5):550-553.

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  19. Apu, A.S., S.S. Husain, M.A.M.Y. Khandoker, A.H.M.S. Rahman, Md. Rashedul Islam, A.S.M.A. Kabir. 2008. Productive and Reproductive potential of indigenous and crossbred dairy cows under farm condition. International Journal of Bioresearch 5(4):26-32.

  20. Md. Rashedul Islam, M.A.M.Y. Khandoker. S. Afroz, M.G.M. Rahman, R.I. Khan. 2007. Qualitative and quantitative analysis of goat ovaries, follicles and oocytes in view of in vitro production of embryos. Journal of Zhejiang University Science B 8(7):465-469.

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  21. Md. Rashedul Islam, S. Afroz, M.A.M.Y. Khandoker, Q.S. Akter, A.H.M.S. Rahman. 2007. Semen characteristics of Black Bengal buck in relation to age, body weight and scrotal circumference. Bangladesh Journal of Agricultural University 6(1):65-71.

  22. Md. Rashedul Islam, S. Afroz, M.A.M.Y. Khandoker, Q.S. Akter. 2007. Motility of fresh and diluted buck semen stored at 5°C. Bangladesh Journal of Animal Science 36(1&2):9-15.

  23. Khandoker, M.A.M.Y., Ali, M.R., Md. Rashedul Islam, Rahman, M.G.M. and Talukder, M.A.S. 2005. In vitro culture of mouse embryos. Progressive Agriculture 16(1):121-128.

  24. Talukder, M.A.S., Md. Rashedul Islam, Khandoker, M.A.M.Y., Afroz, S. and Rahman, M.G.M. 2005. Studies on semen characteristics of different crossbred bulls. Bangladesh Journal of Animal Science 34(1&2):11-16.

  25. Talukder, M.A.S., Khandoker, M.A.M.Y., Rahman, M.G.M., Md. Rashedul Islam and Khan, M.A.A. 2005. Reproductive Problems of Cows at Bangladesh Agricultural University Dairy Farm and Possible Remedies. Pakistan Journal of Biological Science 8(11):1561-1567.

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  26. Goni, M.O., Rahman, M.G.M., Md. Rashedul Islam, Khandoker, M.A.M.Y. and Talukder, M.A.S. 2005. Reproductive and productive performances of different dairy breeds at Baghabarighat Milk Producer’s Co-operative Union Limited. Bangladesh Journal of Animal Science 34(1&2):27-36.

  27. Husain, S.S., Munim, T. Khandoker, M.A.M.Y. and Md. Rashedul Islam. 2005. Morphometric differences among different sub-populations of Black Bengal goat. Progressive Agriculture 16(2):83-89.

  28. Md. Rashedul Islam, S. Afroz, M.A.M.Y. Khandoker. 2004. In vitro maturation, fertilization and subsequent development of goat oocytes. Molecular Biology and Biotechnology Journal 2(1&2):45-48.

Conference Papers

  1. Md. Khayrul Basher, Sumon Sarkar, Md. Rashedul Islam. 2023. The ameliorative effect of selenium on inorganic arsenic-induced estrous cycle disturbance, pregnancy complications, defective fetal and post-natal growth in mice. Proceedings of the 5th International Conference on Biotechnology in Health and Agriculture held in Dhaka, Bangladesh from September 01, 2023, to September 03, 2023.

  2. Md. Rashedul Islam, Soumen Paul. 2022. Inorganic arsenic influence trophoblast lineage development through its impact on self-renewal and compromised differentiation. Proceedings of the BCSIR Congress held in Dhaka, Bangladesh from December 01, 2022 to December 03, 2022.

  3. Md. Samiul Haque, Md. Khayrul Basher, Md. Rashedul Islam. 2022. Toxic effects of inorganic arsenic on body growth and different organs of adult female mice. Journal of Bangladesh Academy of Sciences (2022); 46 (Suppl 1) pp 100.

  4. Md. Khayrul Basher, Md. Samiul Haque, Md. Rashedul Islam. 2022. Inorganic arsenic exposure during pregnancy affects post-natal growth, blood parameters and organ development of mice offspring. Journal of Bangladesh Academy of Sciences (2022); 46 (Suppl 1) pp 49.

  5. Md. Khayrul Basher, Sumon Sarkar, Md. Rashedul Islam. 2022. Impact of inorganic arsenic on estrous cycle, pregnancy outcomes, and post-natal growth in mice. Proceedings of 1st Jamal Nazrul Islam National Conference-2022 for Young Researchers, held in Chittagong University on 21 May 21, 2022.

  6. Md. Rashedul Islam, Soumen Paul. 2021. Inorganic arsenic disrupts trophoblast lineage development and placenta formation: evidence from mouse trophoblast stem cell. Proceedings of International Conference on Science and Technology for Celebrating the Birth Centenary of Bangabandhu held in Dhaka, Bangladesh from March 11, 2021 to March 13, 2021.

  7. Taisuke Fujihara, Seiya Yamashita, Kaname Nishino, Md. Rashedul Islam, Nobuhiko Yamauchi. 2017. Regulation of MMPs via type I interferon in the bovine endometrium during implantation stage. Proceedings of Society for the Study of Reproduction (SSR): 4th World Congress of Reproductive Biology (WCRB 2017) will be held in Okinawa, Japan from September 27, 2017 to September 29, 2017.

  8. Kaname Nishino, Taisuke Fujihara, Md. Rashedul Islam, Nobuhiko Yamauchi. 2016. Expression analysis of β-catenin in bovine endometrium. 121st Japanese Society of Animal Science annual meeting held in Japan from March 27, 2016 to March 30, 2016.

  9. Md. Rashedul Islam, Yuka Yoshii, Yuko Ikeguchi, Mohamed El-Sharawy Nobuhiko Yamauchi. 2016. Development of an in vitro model to study uterine functions using in vitro cultured rat uterine explants. Proceedings of 17th AAAP Animal Congress held in Japan from August 22, 2016 to August 25, 2016.

  10. Hironori Masaka, Sayed Ali Askar Musavi, Md. Rashedul Islam, Nobuhiko Yamauchi. 2016. Screening of embryo secreted factors using bovine elongated embryos. Proceedings of 17th AAAP Animal Congress held in Japan from August 22, 2016 to August 25, 2016.

  11. Sayed Ali Askar Musavi, Kouske Tashiro, Hironori Masaka, Md. Rashedul Islam, Nobuhiko Yamauchi. 2016. Differential gene expression analysis in bovine uterus at follicular, luteal and implantation stage. Proceedings of 17th AAAP Animal Congress held in Japan from August 22, 2016 to August 25, 2016.

  12. Mohamed El-Sharawy, Asami Tanaka, Hikaru Suyama, Md. Rashedul Islam, Nobuhiko Yamauchi. 2016. Effect of cdc42 inhibitor on maturation rate of mouse cumulus and denuded oocytes during in vitro maturation. Proceedings of 17th AAAP Animal Congress held in Japan from August 22, 2016 to August 25, 2016.

  13. Md. Rashedul Islam, Yuka Yoshii, Yuko Ikeguchi, Nobuhiko Yamauchi. 2016. Co-culture of embryos and uterine explants to develop an in vitro model of early implantation. Proceedings of 109th Society for Reproduction and Development Annual Meeting held in Japan from September 11, 2016 to September 15, 2016. Vol. 62, Suppl. j 67.

  14. Yuko Ikeguchi, Md. Rashedul Islam, Nobuhiko Yamauchi. 2016. Expression and regulation of FGFRs in rat uterus. Proceedings of 109th Society for Reproduction and Development Annual Meeting held in Japan from September 11, 2016 to September 15, 2016. Vol. 62, Suppl. j 130.

  15. Md. Rashedul Islam, Kazuki Yamagami, Yuka Yoshii, Nobuhiko Yamauchi. 2015. In Vitro Culture of Rat Uterine Explants: Characterization, Hormonal Regulation and In Vitro Decidualization. Proceedings of 108th Society for Reproduction and Development Annual Meeting held in Japan from September 17, 2015 to September 20, 2015. Vol. 61, Suppl. j 144.

  16. Yuka Yoshii, Kazuki Yamagami, Md. Rashedul Islam, Nobuhiko Yamauchi. 2015. Expression and Localization of Sulf 1 in rat uterus. Proceedings of 108th Society for Reproduction and Development Annual Meeting held in Japan from September 17, 2015 to September 20, 2015. Vol. 61, Suppl. j 140.

  17. Kazuki Yamagami, Md. Rashedul Islam, Yuka Yoshii, Nobuhiko Yamauchi. Preimplantation embryo-derived factors modulate maternal gene expression in the rat uterus. Proceedings of Society for the Study of Reproduction (SSR) 2015 Annual Meeting held in San Juan, Puerto Rico, USA from June 18, 2015 to June 22, 2015.

  18. Nobuhiko Yamauchi, Seiya Yamashita, Taisuke Fijihara, Ryo Tanaka, Md. Rashedul Islam. Type I interferon regulates Matrix Metalloproteinases (MMPs) expression of the bovine endometrial cells in vitro. Proceedings of Society for the Study of Reproduction (SSR) 2015 Annual Meeting held in San Juan, Puerto Rico, USA from June 18, 2015 to June 22, 2015.

  19. Kazuki Yamagami, Yuka Yoshii, Md. Rashedul Islam, Nobuhiko Yamauchi. 2015. Maternal gene expressions regulated by the embryo secreted factors in the rat uterus. Proceedings of 33rd Japan Society of Fertilization and Implantation annual meeting held in Japan from November 26, 2015 to November 27, 2015.

  20. Md. Rashedul Islam, K. Yamagami, Y. Yoshii, N. Yamauchi and Masa-aki Hattori. 2014. Effects of Epidermal Growth Factor and Hepatocyte Growth Factor on Rat Endometrial Epithelial Cells Proliferation, Migration and Lumen Formation In Vitro. Proceedings of 16th AAAP Animal Congress held in Indonesia from November 10, 2014 to November 14, 2014.

  21. K. Yamauchi, N. Yamauchi, K. Yamagami, S. Yamashita, Md. Rashedul Islam, S. Tabata, K. Yahiro, T. Tamura and Masa-aki Hattori. 2014. Development of an in vitro model for the analysis of bovine endometrium using Micro Sphere Array. Proceedings of 16th AAAP Animal Congress held in Indonesia from November 10, 2014 to November 14, 2014.

  22. Md. Rashedul Islam. 2011. In vitro production (IVP) of embryos: Biotechnological perspective for livestock improvement and medical research in Bangladesh. Proceedings of the Conference on “Popularization of Black Bengal Goat Farming: Need Policy Intervention, People’s Participation and Promotion” held on April 16, 2011, Bangladesh.

  23. Md. Rashedul Islam and M.S. Ahasan. 2011. Primordial germ cell preservation: an emerging tool for poultry species conservation. Proceedings of 7th international poultry show and seminar; WPSA-BB, 25-27 March 2011, Dhaka, Bangladesh. Pp 283-289.

  24. Islam, M. R., M.A. Haque, M. S. Ahasan and Md. Rashedul Islam. 2011. The roles of a max yeast culture probiotic in potentiating the body performance dynamics of commercial broiler. Proceedings of 7th international poultry show and seminar; WPSA-BB, 25-27 March 2011, Dhaka, Bangladesh. Pp 310-317.

  25. Md. Rashedul Islam, Sadia Afroz, M.A.M.Yahia Khandoker. 2007. Collection, in vitro maturation, fertilization and subsequent development of goat oocytes in view of in vitro production (IVP) of embryos. Proceedings of the conference on “Promoting Biotechnology in Bangladesh: National and International Perspectives” held on April 6, 7 & 8, 2007 in Dhaka, Bangladesh.

  26. Khandoker, M.A.M.Y., Afroz, S., Md. Rashedul Islam and Husain, S.S. 2006. Cryopreservation of Black Bengal Buck Semen. Proceedings of 12th AAAP Animal Congress 2006 held in Korea from September 18, 2006 to September 22, 2006.

  27. Khandoker, M.A.M.Y., Ali, M.R., Md. Rashedul Islam, Rahman, M.G.M. and Talukder, M.A.S. 2005. In vitro culture of mouse embryos. Proceedings of the Bangladesh Agricultural University Research Progress 16: 34, held in 29-30 November 2005.

  28. Khandoker, M.A.M.Y. and Md. Rashedul Islam. 2005. In vitro culture of bovine embryos. Proceedings of the Bangladesh Agricultural University Research Progress 16: 34, held in 29-30 November 2005.

Books

  1. Md Rashedul Islam. 2010. Collection, in vitro maturation and fertilization of goat oocytes. VDM Verlag Dr. Müller (November 18, 2010).

Others

  1. Md. Rashedul Islam. 2016. Development of an In Vitro Model to Study Uterine Functions and Early Implantation. PhD thesis submitted to Kyushu University, Japan.

  2. Md. Rashedul Islam. 2013. Investigating the effect of Acanthamoeba on Protease Activated Receptor 2 (PAR-2) in a THP-1 Macrophage Cell Line. Master of Science in Biotechnology (MSc Biotechnology) thesis submitted to University of the West of Scotland, United Kingdom.

  3. Md. Rashedul Islam. 2005. Collection, in vitro maturation and fertilization of goat oocytes. Master of Science in Animal Breeding and Genetics (MS in Animal Breeding and Genetics) thesis submitted to Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.


Awards and SCHOLARSHIPS

  1. Japanese Government (MONBUKAGAKUSHO) Scholarship

    Funded by: Ministry of Education, Sports and Culture (MEXT), Japan

  2. Commonwealth Shared Scholarship

    Funded by: Commonwealth Scholarship Commission in the United Kingdom


PROJECTS

  1. Influence of gender on transgenerational effects of inorganic arsenic in post-natal growth, blood profile, and organ development

    Funded by: Ministry of Science and Technology, Government of the People’s Republic of Bangladesh

    Position: Principal Investigator (PI)

    Description: The proposed research project is envisioned to uncover the influence of gender on the transgenerational effects of inorganic arsenic in body growth, blood profile, and organ development in a mice model. After experimentation, it is expected to disclose the transgenerational effects of inorganic arsenic as well as the influence of gender on it, which will be considered the success of this proposed project.

  2. Sodium arsenite exposure during pregnancy influences post-natal growth, blood indices, & organ development of mice offspring: their amelioration using sodium selenite

    Funded by: Institute of Research and Training (IRT), HSTU, Dinajpur-5200, Bangladesh

    Position: Principal Investigator (PI)

    Description: This research project is expected to reveal the toxic effect of sodium arsenite exposure during pregnancy on postnatal growth, blood indices, & organ development of mice offspring and their potential amelioration using sodium selenite. The research findings will be helpful for policymakers to take a new approach to arsenic-induced toxicity. It is also possible to customize a permissible dose of arsenic in drinking water to create awareness among people to get a healthy generation. This information will further create new prospects for scientists to project an alternative amelioration strategy to minimize arsenic-induced toxicity.

  3. Protective potential of selenium against arsenic-induced hematological, biochemical, and organ development anomalies in adult female mice

    Funded by: Ministry of Science and Technology, Government of the People’s Republic of Bangladesh

    Position: Principal Investigator (PI)

    Description: Arsenic-induced toxicity is considered one of the major health concerns worldwide. The increasing toxicity of arsenic is alarming for the environment and poses a huge threat to global public health. To determine the mode of action of the toxicant, knowledge of the physiological action of the respective toxicant helps to anticipate crucial sub-lethal effects, and analyses of biochemistry, hematology, and histopathology may be utilized. On the other hand, sodium selenite (Na2SeO3) as a potential antioxidant plays a significant role in the amelioration of NaAsO2-induced toxicity. The present study investigated the protective potential of Na2SeO3 on NaAsO2-induced hematological, biochemical, and organ development anomalies in adult female mice. Initially, to diagnose the structural and functional status of an individual exposed to a toxicant blood parameter was analyzed and it was observed that Na2SeO3 could rescue the NaAsO2-induced hematological abnormalities. Then, to detect tissue damage and biomarkers of animals exposed to chronic concentrations of a toxicant, enzyme activities were monitored, and with fewer exceptions, all the biochemical parameters (RBS, Alkaline phosphatase, Total Cholesterol, Triglyceride) were improved after Na2SeO3 treatment. In addition, the evaluation of organs (based on morphology) showed the liver and lungs were severely affected in NaAsO2-exposed mice, which was minimized by Na2SeO3 supplementation. On the other hand, organ to body weight ratio showed that Na2SeO3 minimizes the toxic effects of Na-arsenite (NaAsO2) on different organs. Overall, these results suggest that Na2SeO3 can be potential against NaAsO2-induced hematological, biochemical, and organ development anomalies in adult female mice, and further experimentation is needed to clarify the effect of NaAsO2 in the later life of offspring as well as their amelioration strategy.

  4. Toxic effects of inorganic arsenic on body growth and different organs of adult female mice

    Funded by: Institute of Research and Training (IRT), HSTU, Dinajpur-5200, Bangladesh

    Position: Principal Investigator (PI)

    Description: Arsenic-induced toxicity is considered one of the major health concerns worldwide. It is now apparent that chronic arsenic exposure disrupts fetal growth and development both in humans and animals. However, the effect of inorganic arsenic on body growth which further reflects organ development and functions is largely unexplored due to the lack of appropriate experimental model systems. Thus, the present study investigated the toxic effects of inorganic arsenic on body growth and organ development using a mice model. Mice were randomly divided into five groups and exposed to NaAsO2 at 0, 1, 10, 50, and 100 micro molars through drinking water. Initially, it was observed that a higher dose of sodium arsenite interrupts the body growth in mice. Then the body weight gain and rate of body weight gain were compared weekly basis and found that in the 5th week all the treatments showed an increasing trend in this study. Regarding the effect of NaAsO2 on organ development, evaluation of organs showed the liver and lungs were severely affected in NaAsO2 exposed mice, whereas the spleen, kidney, heart, and uterus were morphologically normal both in control and NaAsO2 exposed mice. Furthermore, organ weight and organ-to-body weight were evaluated, and NaAsO2 showed a deleterious effect on organ and organ-to-body weight. Overall, findings suggest that inorganic arsenic interrupts mice's body growth and organ development.

  5. Ameliorative effect of selenium on arsenic induced placental malformations, defective fetal and post-natal growth & development

    Funded by: Ministry of Science and Technology, Government of the People’s Republic of Bangladesh

    Position: Principal Investigator (PI)

    Description: Sodium arsenite (NaAsO2) as an endocrine disruptor interrupts reproduction and poses a risk for offspring’s health outcomes later in life. Sodium selenite (Na2SeO3) as a potential antioxidant plays a significant role in the amelioration of NaAsO2 induced toxicity. The present study investigated the ameliorative effect of Na2SeO3 on NaAsO2 induced reproductive cyclicity, pregnancy initiation, pregnancy outcomes, and post-natal (birth to weaning) growth of offspring in mice. Initially, reproductive cyclicity was evaluated and found that Na2SeO3 could minimize estrous cyclicity interruption induced by NaAsO2. Then mice were evaluated for pregnancy initiation based on the presence of conceptuses in the uterine horn and placenta formation at gestation day 12.5. Results showed Na2SeO3 could rescue the NaAsO2 induced pregnancy loss, and the number of conceptuses was significantly (p=<0.002) higher than NaAsO2 exposed mice. Evaluation of conceptuses, placenta, and embryos showed morphologically normal features except for Na2SeO3 treated mice where a rare phenomenon of monochorionic-diamniotic twins was observed. In addition, the evaluation of organs (based on morphology) showed the liver and lungs were severely affected in NaAsO2 exposed mice, which was minimized by Na2SeO3 supplementation. On the other hand, the spleen, kidney, and heart were morphologically normal in all exposed mice. Once we observed that NaAsO2 influences placenta formation at E12.5, we initiated NaAsO2 exposure at gestation day 12.5 until parturition to examine the pregnancy outcome. Results showed that litter size and litter weight was improved after Na2SeO3 treatment, although the differences were not at a significant level. On contrary, weight/pups were reduced in Na2SeO3 treated mice when compared with NaAsO2 treated mice. Then the study evaluates the post-natal (birth to weaning) growth performance of offspring obtained from control, NaAsO2, NaAsO2+Na2SeO3, and Na2SeO3 treated mice. Results showed that the final body weight, total body weight gain, and rate of body weight gain were significantly (p=<0.01) hampered in offspring obtained from NaAsO2 treated mice than offspring of non-treated control mice, and Na2SeO3 could not minimize the effects of NaAsO2 in this study. Data revealed that in offspring obtained from both control and NaAsO2 treated groups, the rate of body weight gain was significantly (p=<0.005, p=<0.02 respectively) higher in males than females. Additionally, in offspring obtained from NaAsO2+Na2SeO3, and Na2SeO3 treated group mice, the rate of body weight gain was higher in males than females, although the differences were not at a significant level. Overall, these results suggest that Na2SeO3 can be potential against NaAsO2 induced reproductive toxicity, and further experimentation is needed to clarify the effect of NaAsO2 in the later life of offspring as well as their amelioration strategy using Na2SeO3.

  6. Impact of chronic arsenic exposure on placenta formation, fetal and post-natal growth & development

    Funded by: Institute of Research and Training (IRT), HSTU, Dinajpur-5200, Bangladesh

    Position: Principal Investigator (PI)

    Description: Inorganic arsenic (NaAsO2) as an endocrine disruptor interrupts reproduction and poses a risk for offspring’s health outcomes later in life. The study investigated the effect of NaAsO2 on reproductive cyclicity, placenta formation, pregnancy outcomes, and post-natal (birth to weaning) growth of offspring in mice. Initially, reproductive cyclicity was evaluated and found that NaAsO2 interrupts the estrous cyclicity and the estrus stage was significantly (p=<0.05) influenced by NaAsO2. Then mice were evaluated for pregnancy and placenta formation at E12.5. Results showed the number of conceptuses was significantly (p=<0.001) higher in control than NaAsO2 exposed mice. Evaluation of conceptuses, placenta, and embryos showed morphologically normal features. In addition, evaluation of organs showed the liver and lungs were severely affected in NaAsO2 exposed mice, whereas the spleen, kidney, and heart were morphologically normal both in control and NaAsO2 exposed mice. Once we confirm that NaAso2 influences placenta formation at E12.5, we initiated NaAsO2 exposure at gestation day 12.5 until parturition to examine the pregnancy outcome. The litter size and litter weight were comparatively higher in NaAsO2 exposed mice, although the differences were not at a significant level. Similarly, weight/pups were significantly (p=<0.01) higher in NaAsO2 exposed mice compared to control mice. The organ morphology after parturition showed the liver and lungs were severely affected in NaAsO2 exposed mice. Finally, post-natal (birth to weaning) evaluation showed the final body weight (p=<0.002), total body weight gain (p=<0.001), and rate of body weight gain (p=<0.001) hampered significantly in offspring obtained from NaAsO2 exposed mice. Additionally, the rate of body weight gain was significantly (p=<0.005, p=<0.02 respectively) higher in males than females. Overall, findings suggest that inorganic arsenic interrupts reproduction in mice and further experimentation is needed to clarify the effect of inorganic arsenic in the later life of offspring as well as their amelioration strategy.


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